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(13:41 13/07/02) shov emil1q1 בושח והשמ םורופב םלוכלו יתיאל

(15:21 13/07/02) - יתיא הוועש אל וז

(13:23 13/07/02) shov emil1q1 קודבתש יאדכש רושיק יתיאל

(15:06 13/07/02) - יתיא יארונ רצומ

(16:19 11/07/02) יפילח יבא לאיראב לפטמ ינא

(19:06 11/07/02) ןולא ליג ? רישכמ הזיא

(23:06 12/07/02) יוסח 16 ןב ןולא ליג התא

(13:43 12/07/02) תוצע דבוא ????????תושעל המ

(14:42 12/07/02) ןולא ליג רזייל

(23:05 12/07/02) יוסח 16 ןב הפ התאש חמש ינא

(23:18 11/07/02) אא קרוי וינ ילש םיבושח םיטרפ דוע

(22:56 11/07/02) אא קרוי וינ ילש ולאקב ינש לופיט

בוש תבתוכ ינאו רבעב יתבתכ
ולאקב ינש לופיט יתלחתה לומתא
יתיאמ ץוח ולאק תא הסינ הפמ ימ תעדוי אל
דדיה דדיה !!!! רתוי םינועצפ יל ןיא...הצורמ שממ ינא לבא
תורעש יתדרוה תוחרק ןומה םע תולילד שממ יל ולדגש תורעשהו
תועש יל חקולש ללכ ךרדבמ ןמזה תיצחמ יל חקלו הנוכמ םע לומתא
תורדוחש תורעשה תא איצוהל ידכ) הטצניפה םע תשאימ תוקסעתה םע
) רועל תחתמ
אוה תוחל םע לבא לוהוכלא ומכ אוהש רמוחב יתשמתשה ולאקמ ץוח
תא יל שדיח הז ( ףוזיש ירחא ומכ) רועה לש ןידע ףוליקל םרג
.םויה ןיטולחל אירב אוהו רועה
רזוע הזש הפיל םע אל םוי ןכ םוי ףוגה תא ןבסל יתגאד םגו
.רועל תחתמ לודגלו בושל אל תורעשל
80%ו םינועצפ אלמ העווז הארנ היה ילש רועהש ןייצל תבייח ינא
.רועל תחתמ יל תולדג ויה תורעשהמ
עגמה הררח ומכ הארנ היה הז יכ רצק סנכמ תשבול יתייה אל םעפ ףא
...הוועש ירחא וליפא דימת ספסוחמ היה
ןיב בולישהש תרעשמ ינא לבא לכה ךסב דחא לופיט ירחא היה הז לכ
.הלאה תואלפנה תואצותל ומרג הפיל םע ףוגה לש ןוביסהו םירמוחה
ימ בוש...ילש טויסה היה הז יל הרוק הזש הנימאמ אל ןיידע ינא
ןכדועמ אלש
הריעש יד ינא הנותחתה ןטבבו תועשפמב םיילגרב לופיטה תא יתישע
עבצב היה ןועצפ לכו..תובעו תורוחש ויה תורעשהו תונבל תיסחי
!!
םיעצפהש יתבשח יכ םורופב בותכל יתיצר אל םלהב יתייה הלחתהב
תורעשה ולדגישכ ורזחי
!!!!!!!!!! אל לבא
ופט ופט ופט
ארקנ וב יתשמתשהש ינשה רמוחהו ץראב ולאק ןיאש תעדוי ינא
TEND SKIN THE SKIN CARE SOLUTION
...ץראב םייק הז םא וררבת
...םכל חולשלו הצורש ימל רוזעל הנכומ ינא
ילש האצותל םרג הלאה םירבדה תשולש לש בוליש חוכשל אלו
ולאק
TEND SKIN
( גופס אל) הפיל םע בוט בוט ןוביסו
למייאב ילא תונפל רשפא

רשק רוצ

העדוה ספדה הכנת ההודעה להדפסה

רבחל חלש

הבוגת

:תויורשפא

(19:26 10/07/02) ןולא ליג [ת"ל] !!!!!םיאמר תוריהז

(19:31 10/07/02) ןולא ליג םיאמרה הלא

(23:21 09/07/02) קינ לכימ ? הרסהל םרק ,2000 ידייל לע םתעמש

(01:18 10/07/02) - יתיא [ת"ל] קמועל ררבל הסנא ינא

(01:40 10/07/02) - יתיא יתקדב בוט

(02:44 10/07/02) יוסח 16 ןב ללכב םהמ הנקת לא

(20:57 07/07/02) טייט ןב הוועש רחאל םיעצפ

(22:06 09/07/02) יוסח 16 ןב העודי היעב תאזש דיגהל קר לוכי ינא

(13:52 07/07/02) יוסח 16 ןב ?CRYSTAL 512 הז המ

(18:28 07/07/02) - יתיא חוטב 16-17 יאליגל

(01:04 08/07/02) יוסח 16 ןב ש בושח ינא

(19:02 08/07/02) - יתיא ןיינעה אל הז

(22:02 09/07/02) יוסח 16 ןב בוט אל הזו םינש 4 הז 20 ליג דע

(19:09 07/07/02) - יתיא ףסונ החימצ אכדצ

(00:03 04/07/02) - יתיא חותיפב רצומ

רעישה תא תיחפיש רצומ תחתפמ תרדהנה ןוסנו'ג דנא ןוסנו'ג תרבח
השענש רקחמ לע ךתסמ לבא השינאו לש ןונגסב והשמ -ףוגה לעש
דועב קוושי ילוא רצומה הרבחהמ יתלביקש ליימיאמ .היוס ילופב
םכתיא ינא -םכל רזוע הז םא !םש דמעמ וקיזחת זא םישדוח רפסמ
:רמאמה ףרוצמ

Soymilk reduces hair growth and hair follicle dimensions
Seiberg, J.-C. Liu, L. Babiarz, E. Sharlow and S. Shapiro
M.
and alter the pattern of melanogenic gene expression.
the rate of hair growth, decrease hair shaft dimensions
for hair care and management. These agents could reduce
protease inhibitors could be used as effective agents
level, that soymilk and the soybean-derived serine
first evidence, at the morphological and histological
appearance of the hair. The studies presented here provide
dimensions of the hair follicle and hair shaft, and the
hair pigmentation, but also the rate of hair growth, the
Interestingly, these agents were found to affect not only
effect of STI, BBI and soymilk on hair pigmentation.
The present studies were initiated to examine the possible
could be used as a natural alternative to skin lightening.
extracts alter skin pigmentation, suggesting that soymilk
soybean-derived serine protease inhibitors and soybean
Abstract: We have recently shown that

understand the regulation of hair growth and cycling.
mouse model (3, 4) has been extensively utilized to better
is not completely understood. The synchronized hair growth
but the regulation of the different phases of this cycle
changes throughout the hair cycle are well-documented (2),
shaft remains inside the short follicle. The morphological
in telogen the epithelial cells are resting while the hair
shaft. During catagen the hair follicle shortens, and
forming a complex layered structure with a pigmented
anagen the hair follicle grows down into the dermis,
regression (catagen) and rest (telogen) (1). During
structure that undergoes cycles of active growth (anagen),
The hair follicle is an epithelial

shafts are always darker than the already treated parts.
always satisfying, as the emerging portions of the hair
These treatments, which are sometimes irritating, are not
used to reduce hair visibility in desired body parts.
hair cosmetic treatments like hair dying or bleaching,
of antiandrogens. Alternatives to hair removal are popular
toxicity or effects on muscularity often accompany the use
pigmentation. Several unwanted side effects, such as liver
treatments, but not without changes in skin texture and
Promising clinical results have been obtained with laser
expensive and painful and may further result in scarring.
hair for a prolonged period of time, the process is
hair. While electrolysis may keep an area free of unwanted
and discomfort, and often results in poor removal of short
may also leave undesirable stubble. Plucking causes pain
perception of an increase in the rate of hair growth, and
surface, may increase the risk of infection, may leave a
in (5)). Shaving may result in nicks and cuts in the skins
but also in their possible undesired effects (reviewed
their price range and their pain and discomfort levels,
methods differ not only in the duration of hair removal,
light therapies and therapeutic antiandrogens. These
time-consuming methods like electrolysis, laser,
shaving, plucking and waxing, to expensive and potentially
hair, from simple inexpensive home treatments like
purposes. Many procedures are used to remove unwanted
in whom hair is kept or removed for social and cosmetic
However, that function has been lost in humans,
of mammalian hair is to provide environmental protection.
One main function

INTRO

natural alternative treatment for undesired hair growth.
data suggest that such agents may serve as an inexpensive,
growth and the final dimensions of the hair shaft. These
not only hair pigmentation, but also the rate of hair
Our data demonstrate that STI, BBI and soymilk reduce
of these agents in the inhibition of hair pigmentation.
described here were designed to explore the potential use
and thus induce skin depigmentation (9). The studies
that soymilk, STI and BBI inhibit PAR-2 activation
trypsin and chymotrypsin (7, 8). Recently we demonstrated
the proteolytic activity of trypsin (6), and BBI inhibits
isolated from soybeans (reviewed in (6, 7)). STI inhibits
inhibitor (BBI) are two serine protease inhibitors
trypsin inhibitor, STI), and the Bowman-Birk protease
The Kunitz-type trypsin inhibitor (soybean

DISCUSSION

follicle and hair shaft, and the appearance of the hair.
also the rate of hair growth, the dimensions of the hair
were found to affect not only hair pigmentation, but
soymilk on hair pigmentation. Interestingly, these agents
initiated to examine the possible effect of STI, BBI and
to skin lightening (9). The present studies were
that soymilk could be used as a natural alternative
by soymilk leads to skin depigmentation, suggesting
agents. Similarly, inhibition of the PAR-2 pathway
in skin lightening, suggesting a new class of depigmenting
by synthetic serine protease inhibitors (15, 17) results
The inhibition of PAR-2 activation

soymilk that affects hair growth, sìze and pigmentation.
it is more likely that STI is the major protein agent in
is heat labile, but BBI is less affected by heat (6, 21),
the active inhibitor in our hair growth studies. Since STI
but not heat-denatured or pasteurized soymilk, was
edible. It is important to note that fresh soymilk,
processing (reviewed in (19, 20)) that renders the soybean
It is the heat inactivation of STI and BBI during soybean
and other proteases needed for protein digestion (18).
activity of STI and BBI, which block the action of trypsin
serious gastric distress. These are due to the inhibitory
techniques were developed, because they produced
not utilized as food until precipitation and fermentation
Soybeans were

show an additive effect, until saturation is observed.
Moreover, the combinations of soy and isoflavones tested
that they affect hair growth via a different pathway.
are not known to act via the estrogen receptor, we suggest
STI and BBI, alone, affect hair growth. Since these agents
also show that the soy-derived serine protease inhibitors,
isoflavones in the regulation of hair growth. However, we
culture (16). Our data clearly demonstrate a role for soy
follicles isolated from scalp biopsies were treated in
was shown to decrease hair growth by 60%-80%, when hair
Interestingly, the soy derived phytoestrogen genistein
estrogenic effects of isoflavones are heavily documented.
pathway in the regulation of the hair cycle (23). The weak
These studies implicate a skin-specific estrogen receptor
sites, indicating a direct rather than systemic effect.
more effective at the site of application than at distant
hair growth in this system (22, 23). This treatment was
in mice, while an estrogen receptor antagonist initiated
treatments with 17-beta-estradiol inhibited hair growth
Topical

deposition are required to substantiate this hypothesis.
studies that induce PAR-2 activation and enhance pigment
within the hair follicle via the PAR-2 pathway. However,
could also imply that soymilk reduces pigment deposition
protein levels following soymilk treatment. These data
suggestion, demonstrating reduced tyrosinase and TRP-1
should be reduced. Our current hair studies support this
serine protease inhibitor, its steady state protein level
that while tyrosinase mRNA levels were not affected by the
and reduced pigment production (15). This suggests
led to reduced tyrosinase half life and activity,
we suggested that the down regulation of TRP-1 expression
of tyrosinase by stabilizing the protein (24, 25),
tyrosinase gene expression (15). As TRP-1 is a regulator
a decrease in TRP-1 gene expression, but in no changes in
of keratinocyte-melanocyte co-cultures results in
A serine protease inhibitor treatment

effect on hair growth and sìze via a different mechanism.
and BBI do not affect papillae cell death, but exert their
STI or BBI treated mice (not shown), we suggest that STI
not detect apoptotic cells in the papillae of soymilk,
pigment deposition within the hair shaft. Since we could
as well as to reduced follicle dimensions and reduced
inhibitors STI and BBI also lead to delayed hair growth,
and pigmentation (26). Here we show that the trypsin
activity of the protease, resulted in delaying hair growth
This death signal, which is independent of the proteolytic
depilation, induced cell death at the follicular papilla.
showed that topical trypsin treatment, immediately after
Using the synchronized hair growth mouse model (3, 4) we

and made the hair softer, finer and less noticeable.
the direction of hair growth to look more homogeneous,
reduced the rate of hair growth of womens legs, affected
that treatment with soymilk-containing formulations
data of these studies (J.-C. Liu, in preparation) indicate
led us to perform larger double blind studies. Preliminary
represent a positive proof-of-concept pilot study, which
unwanted hair growth. The human studies presented here
and could serve as an effective natural way to manage
provides a new concept in hair growth and management,
growth and reduce hair shaft dimensions and pigmentation
and soymilk-derived serine protease inhibitors delay hair
which are not always satisfying. The finding that soymilk
pigmentation would add to the available home treatments,
agent that could reduce hair growth, hair sìze and hair
is bleached to reduce its visibility. A safe and effective
removed using home treatments or professional services, or
parts for social and cosmetic purposes. Unwanted hair is
Humans keep or remove hair from different body

reduced womens facial hair growth rate and visibility.
with STI and soymilk-containing formulations significantly
data (J.-C. Liu, in preparation) indicate that treatment
enhancing their quality of life. Preliminary clinical
to reduce hair growth and visibility in these patients,
would be painless and of modest cost and could serve
soybean-derived protease inhibitors or soymilk products
hair removal when affordable (29). Daily treatment with
and electrolysis and thermolysis are used for permanent
are usually used to hide cuts and stubble (27, 28),
pigmentary changes, and scarring. Cosmetic cover-ups
to tolerate and care must be taken to avoid folliculitis,
as plucking, waxing and depilatories are more difficult
the most frequently used temporary method for facial hair,
in the management of hirsute patients. Shaving is
and temporary hair removal is a major component
often interferes with personal and work activities,
condition affecting about 4% of women. Facial hirsutism
Hirsutism is a relatively frequent

hair more manageable, improving its appearance.
could reduce this complexity and make the African-type
addition of STI, BBI or soymilk into hair care products
hair maintains cosmetic desired properties. The
products and procedures to ensure that the African-type
shaft structure creates the need for specialized grooming
kinky hair shaft with variations in diameter. This complex
African-type hair is unique in its morphology - a

and lighter hair shafts, and more manageable hair care.
hair pigmentation, resulting in slower hair growth, softer
of hair growth, decrease hair shaft dimensions and reduce
care and management. These agents could reduce the rate
as effective and inexpensive cosmetic agents for hair
soymilk and the soybean-derived serine protease inhibitors
The studies presented here establish

רשק רוצ

העדוה ספדה הכנת ההודעה להדפסה

רבחל חלש

הבוגת

:תויורשפא

(15:50 06/07/02) shov emil1q1 הדות יתיאל

(13:45 07/07/02) יוסח 16 ןב [ת"ל] רקי הלעי הז םג חטבו

(18:22 07/07/02) - יתיא אל אקוד

(17:28 05/07/02) רורד יבא יוצר אל רעיש

(14:18 06/07/02) - יתיא ....דחא דוע

(13:47 07/07/02) יוסח 16 ןב ...16 ןב ינא ?19 ליג

(13:15 29/06/02) באוכו בהוא ולאקב לופיט יתלחתה ףוס ףוס םויה

(00:05 30/06/02) קינ לכימ ? תינקש החשמה לש תומכה המו ? תלחתה רוזיא הזיאב

(01:00 30/06/02) באוכו בהוא ...החירסמ תומכ חוטבש המ

(21:59 30/06/02) קינ לכימ [ת"ל]

????????????? ח"ש 388 הלוע הנטק כ"כ תרפופש

(20:42 03/07/02) shov emil1q1 ??????ךלש לופיטל קיפסמ הז ךיא

(21:25 03/07/02) באוכו בהוא ...ןויסינמ קיפסי הז

(07:19 04/07/02) א קרוי וינ ילש לופיט ירחא ינא םג

(15:47 06/07/02) shov emil1q1 באובו בהואל

(18:54 06/07/02) באוכו בהוא ..תואצותה יבגל

(13:44 07/07/02) יוסח 16 ןב ףוגב תומוקמ שי

(18:57 30/06/02) ןולא ליג ? החשימ וא יירפס

(21:28 30/06/02) באוכו בהוא !!!םהינש תא יתינק

מ"עב קטביטקא ידי-לע המקוה וז ןויד תצובק

"םירוביד" -ב םניח םורופ חתפ