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תואירבל זכרמה דודו הילד	:םש
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10:19 31/12/10	:ךיראת
הצופנ תשרט ילוחל תחמסמ הרושב	:אשונ

:העדוה

ןורתפה !הצופנ תשרט לש תמולעת הרתפנ MS ילוחל תחמשמ הרושב
הלוח לוכ לש די גשהב
םלועה יבחרמ םיאפור םע דחיב, DR Zamboni יקלטיא רקוחו אפור
:ףתושמ הנכמ MS ילוח תואמ לצא וליג

.חומהמ םדה תא זקנל םירומאש םידירו תוריצה

.וקדבנש םילוחהמ תיברמ לצא התפצנ היעבה

תלוכיהו המיתס החתפנש ושיגרה המיתסה תחיתפל חותינ ורבעש םישנא
הלדג םהלש תויתעונתה

.ןכמ רחאל תשרט יפקתה םהל היה אלו הרפתשהו

הליהקה ,יופצכ, עגרכ,אפור ותוא לש רקחמה תואצות םסרפתי בורקב
,םיאצממה תא לבקל הנכומ אלו קושב תיאופרה

.תויחוורב הקזח העיגפ בקע םתסה ןמ

םש םיטינרבקה לש םהינעמ שארב התייה אל םעפ ףא םילוחה תבוט
.הלעמל

!הצופנ תשרט MS ילוח ץראב םגש הווקת ילוכ

הווקמו,םידירו תוריצה שי םהל םג םאה הקידבלו ןוחבאל וכלי
תויעבב ולפטיו ץראב הפ תוריהמב הפפכה תא ומיריש םיאפור ויהיש
.תוריהמב הלא

CCSVI לש הירואיתב תמא שיש הארמ רקחמ

:טוטיצ

insufficient blood flow out of the brain," said Zivadinov.
all the MS patients, but none of the controls, had chronic
eight age-and-sex-matched healthy controls, showed that
which involved 16 relapsing-remitting MS patients and
"Results of this preliminary study,

יהשלכ המיתס האצמנ וקדבנש MS ילוח 16 הארמ ולפאבמ רקחמ
.םייתיעבכ םיעודיה םידירוב

.תוקידבב המיתס אצמנ אל םיאירב תרוקיב ישנא -8 לו

.שארה תא ובבוסי אלו אשונה תא ודמליש םיאפורה םע ורבד אנא

investigate possible new underlying cause of MS
Buffalo neurologists

prevailing wisdom on the cause of multiple sclerosis (MS).
are beginning a research study that could overturn the
NY – Neurologists at the University at Buffalo
BUFFALO,

"chronic cerebrospinal venous insufficiency," or CCSVI.
of the primary veins outside the skull, a condition called
possibility that the symptoms of MS result from narrowing
The researchers will test the

with MS, increasing the risk of developing MS by 43 fold.
patients, CCSVI was found to be strongly associated
Italy's University of Ferrara. In the original Italian
discovered and described by Paolo Zamboni, M.D., from
CCSVI is a complex vascular condition

causes injury to brain tissue and degeneration of neurons.
the blood flow patterns within the brain that eventually
outflow of blood from the brain, causing alterations in
This narrowing restricts the normal

"it is going to change the face of how we understand MS."
Center (BNAC) and principal investigator on the study,
neurology, director of the Buffalo Neuroimaging Analysis
Robert Zivadinov, M.D., Ph.D., UB associate professor of
venous insufficiency is the underlying cause of MS," said
"If we can prove our hypothesis, that cerebrospinal

persons who now face inevitable lifestýle restrictions."
take their toll could change the lives of millions of
to identify those at risk of developing MS before symptoms
enormous implications for the treatment of MS. "Being able
said a positive outcome from this trial would have
dean of the UB School of Medicine and Biomedical Sciences,
Michael Cain, M.D., professor and

diseases has lead to some very important discoveries.
know that ain't so'. Challenging basic assumptions about
what we don't know that gives us trouble, it's what we do
is located, commented: "Will Rogers once said, 'It isn't
Health, parent of Buffalo General Hospital where the BNAC
vice president and chief medical officer of Kaleida
Margaret Paroski, M.D., executive

whole different way of thinking about multiple sclerosis."
a bacterial infection. Dr. Zivadinov's work may lead to a
to stress. We now know that 80 percent of cases are due to
in medical school, we thought peptic ulcer disease was due
"When I was

occurred more frequently in MS patients than in controls.
that return venous blood from the brain to the heart
several abnormalities affecting the predominant pathways
Fabrizio Salvi, M.D, respectively. The study showed that
of Ferrara and Bologna, Italy, directed by Zamboni and
at the BNAC headed by Zivadinov, and at the Universities
The preliminary findings were based on a pilot study

to replicate the findings of the Italian investigators.
Foundation of Italy and the BNAC, was conducted
This research, supported by the Hilarescere

insufficient blood flow out of the brain," said Zivadinov.
all the MS patients, but none of the controls, had chronic
eight age-and-sex-matched healthy controls, showed that
which involved 16 relapsing-remitting MS patients and
"Results of this preliminary study,

webs within the large veins of the neck and brain"
associated with strictures, malformed valves and peculiar
The method identified anomalies in the venous blood flow
were acquired using a method called Doppler ultrasound.
on the pilot study, added: "The images from this study
professor of neurology and a co-principal investigator
Bianca Weinstock-Guttman, M.D., UB associate

are located in Buffalo General Hospital of Kaleida Health.
(JNI), UB's Department of Neurology. The JNI and BNAC
Sclerosis Center at the Jacobs Neurological Institute
Weinstock-Guttman directs the Baird Multiple

in the flow of cerebrospinal fluid in the MS patients.
scans also revealed increased brain atrophy and changes
location of MS lesions and sites of impaired drainage. The
and showed that those deposits may be associated with the
identified distinct areas of iron deposits in the brain,
(MRI) of the MS study patients conducted at the BNAC also
Advanced magnetic resonance imaging scanning

Sclerosis held in September in Dusseldorf, Germany
European Committee for Treatment and Research in Multiple
investigation, were presented at the 25th Congress of the
These results, which form the basis of the current larger

across the U.S. are eligible to participate in the study.
begun and will continue for two years. MS patients from
neurodegenerative diseases. Enrollment in the study has
controls, and 300 patients with other autoimmune and
possible or definite MS, 300 age-and-sex matched normal
be comprised of 1,100 patients who were diagnosed with
involve 1,600 adults and 100 children. The cohort will
The new study will

in MS and the progressive loss of neurons" said Zivadinov.
demonstrated a significant neurodegenerative component
has been challenged by research findings, which have
immune responses against the patient's nervous tissue
damage in MS is predominantly the result of abnormal
"The prevailing wisdom that central nervous system

remains poorly understood, and its cause remains elusive."
disease. Consequently, the origin and development of MS
it difficult to identify the cause, or causes of the
in MS and vary considerably among patients, making
and neurodegenerative processes occur concurrently
However, these inflammatory

and the extracranial veins, using Doppler ultrasound.
of blood flow through both the brain's blood vessels
the present study, which will evaluate both the velocity
can be repeated, Zivadinov and Weinstock-Guttman organized
To determine if these preliminary findings

Doppler (CTEVD) evaluation in MS and related diseases".
study is "combined transcranial and extracranial venous
The technical name of the

questionnaire to identify potential MS risk factors.
blood samples, and complete an extensive environmental
in different body postures. Participants also will provide
to acquire images of the direction of venous blood flow
examination and a Doppler scan of the head and neck
All study subjects will undergo a general clinical

and psychiatry at the JNI, UB's Department of Neurology.
conducted by Ralph Benedict, Ph.D., professor of neurology
symptoms. The neuropsychological part of the study will be
on these images will be related to neuropsychological
called susceptibility-weighted imaging. Iron findings
lesions and surrounding areas of the brain using a method
will undergo MRI of the brain to measure iron deposits in
All MS patients

of the veins of the neck to confirm diagnosis of CCSVI.
of 250 consecutive patients and controls will undergo MRI
A sub-cohort

risk for developing MS as well as MS disease progression.
and cigarette smoking, which have been linked to increased
of interest in MS research, such as vitamin D metabolites
system injury. He also will be looking for other factors
and soluble factors associated with central nervous
Sciences, will analyze blood samples for proteins
Sciences, UB School of Pharmacy and Pharmaceutical
associate professor in the Department of Pharmaceutical
Murali Ramanathan, Ph.D.,

###

details on the study, send an email to ctevd@bnac.net.
initial unblinding scheduled for November 2009. For more
be unblinded at three predetermined time-points, with the
The data will

trial that will evaluate the occurrence of CCSVI in MS.
the study may lead to a larger multicenter North-American
Zivadinov said results of

is a member of the Association of American Universities.
programs. Founded in 1846, the University at Buffalo
than 300 undergraduate, graduate and professional degree
students pursue their academic interests through more
and most comprehensive campus. UB's more than 28,000
in the State University of New York system and its largest
public university, a flagship institution
The University at Buffalo is a premier research-intensive

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